Simultaneous Spectrophotometric Estimations of Drotaverine Hydrochloride and Omeprazole

Three simple spectrophotometric methods have been developed for simultaneous estimation of Drotaverine HCl and Omeprazole from tablet dosage form. Method-I involves, formation of Q-absorbance equation at 306.0 nm (isoabsorptive point) and 229.5 nm (lmax of drotaverine); simultaneous equation method (Method-II) and Method-III is the multicomponent mode of analysis in which the inbuilt software calculates the concentration of the sample solution, The absorbances of the standard solutions were taken at two wavelengths 229.5 nm (lmax of drotaverine) and 302 nm (lmax of omeprazole) in methanol and the linearity lies between 1-24 mg/ml for drotaverine and 1-6 mg/ml for omeprazole for all the three methods. The accuracy and precision of the methods were determined and validated stastically. All the methods showed good reproducibility and recovery with % RSD less than 2. All methods were found to be rapid, specific, precise and accurate and can be successfully applied for the routine analysis of drotaverine and omeprazole in bulk and combined dosage form.